United States government. Defense Nuclear firms, Hoffman-LaRoche and Ciba-Geigy, and by Agency, Armed Forces Radiobiology Research In­ the American firm, Travenol. stitute. SIEGMUNDJ. BAUM Furthermore, we greatly appreciate the gener­ G. DAVID LEDNEY ous financial support by the Swiss pharmaceutical vi Xlll List of Contributors Part I Regulation of Stem Cell Proliferation L. G. Lajtha 1 Regulation of Stem Cell Proliferation 3 L. G. Lajtha and E. G. Wright Introduction 3 Experimental Evidence 3 Summary 7 References 7 Contents 2 Surface Antigens of Hemopoietic Stem Cells: The Expression of BAS, Thy-1, and H-2 Antigens on CFU-s 9 Ger van den Engh, Jim Russell, and Diane de Cicco Introduction 9 Materials and Methods 10 Results 11 Discussion 13 Summary 14 Acknowledgments 14 References 15 3 The Regulation of Hemopoiesis: Effect of Thymosin or Thymocytes in a Diffusion Chamber 17 S. J. Sharkis, A. Ahmed, L. L. Sensenbrenner, W. W. Jedrzejczak, A. L. Goldstein, and K. W. Sell Introduction 17 Materials and Methods 17 Results 18 Discussion 20 Summary 21 Acknowledgments 21 References 21 4 Anti-CFU-s Activity of Rabbit Anti­ mouse Brain Serum: Mechanism of Action 23 Solomon S. Adler, Richard D. Kuznetsky, and Frank E. Trobaugh, Jr. Introduction 23 Materials and Methods 23 Results 26 Discussion 29 Summary 31 Acknowledgments 31 References 31 vii Contents Part II Ralph van Furth, Theo J. L. M. Goud, and Physiology of Committed Dick van Waarde Stem Cells 33 Introduction 65 D.

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InhaltsangabeI Regulation of Stem Cell Proliferation.- 1 Regulation of Stem Cell Proliferation.- Experimental Evidence.- Summary.- References.- 2 Surface Antigens of Hemopoietic Stem Cells: The Expression of BAS, Thy-1, and H-2 Antigens on CFU-s.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 3 The Regulation of Hemopoiesis: Effect of Thymosin or Thymocytes in a Diffusion Chamber.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 4 Anti-CFU-s Activity of Rabbit Anti-mouse Brain Serum: Mechanism of Action.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- II Physiology of Committed Stem Cells.- 5 The Control of Neutrophil and Macrophage Production at the Progenitor Cell Level.- Granulocyte-macrophage Colony-forming Cells.- Control by GM-colony-stimulating Factor (GM-CSF).- Nature and Sources of GM-CSF.- Role of Macrophages and Lymphocytes.- GM-CSF and Myeloid Leukemia.- General Comment.- Summary.- Acknowledgment.- References.- 6 The Mononuclear Phagocyte and Its Regulatory Interactions in Hemopoiesis.- Dualism between CSF and Synthetic Prostaglandins.- Cyclic 3?,5-Adenosine Monophosphate in the Mediation of PGE Activity.- Regulation of Granulopoiesis and Macrophage Production by Macrophage-derived PGE.- The Regulatory Role of Macrophages in Lymphopoiesis.- The Macrophage and Other Hemopoietic Cells.- Summary.- References.- 7 Analysis of the Cells Forming Pure and Mixed Erythroid Colonies in Agar after Stimulation by Pokeweed Mitogen-stimulated, Spleen-conditioned Medium.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- 8 Current Studies on the Proliferation of Cells of the Mononuclear Phagocyte System.- Origin and Kinetics of Mononuclear Phagocytes.- Regulation of Monocyte Production.- In Vitro Proliferations of Bone Marrow Mononuclear Phagocytes.- Summary.- Acknowledgment.- References.- 9 Colony-forming Cells in the Thymus and Mesenteric Lymph Nodes of Mice Engrafted with Lewis Lung Carcinoma Cells.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- III Transplantation Immunology.- 10 Expression of Normal and Leukemia associated Antigens on Blood Cell Malignancies.- Materials and Methods.- Results and Conclusions.- Summary.- Acknowledgment.- References.- 11 Leukocyte Transfusions for the Modification of Host-versus-graft Reactions in Dogs.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- 12 Minor Histocompatibility Systems in Dogs.- Materials and Methods.- Results.- Discussion.- Acknowledgments.- Summary.- References.- 13 The Role of Mononuclear Phagocytes in the Defense against Infections and Malignancies.- Macrophages and the Immune Response.- Effects of the Humoral Immune Response on Macrophage Functions.- Effects of the Cell-mediated Immune Response on Macrophage Functions.- Microbiocidal Mechanisms of Macrophages.- Role of Macrophages in the Defense against Neoplastic Disease.- Summary.- Acknowledgment.- References.- 14 Enhancement of Immunological Responses by Methotrexate Pretreatment as a Result of an Eventual Elimination of Suppressor Cells.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- 15 Syngeneic and Autologous Bone Marrow Transplantation after Noncurative Chemotherapy with AAFC, DMM, and Cyclophosphamide in Tumor-bearing Mice.- Materials and Methods.- Preparation of Cel Inocula.- Treatment of Bone Marrow Cells with Anti-Thy 1.2 Serum plus Complement.- Immunization Procedures.- X-irradation.- Statistical Analysis.- Experimental Design.- Results.- Discussion.- Summary.- Acknowledgements.- References.- IV Therapeutic Approaches to Aplastic Anemia.- 16 On the Pathogenesis and Treatment of Aplastic Anemia.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgements.- References.- 17 Engraftment of HLA Identical Marrow in Treatment of Severe Apla