The latest developments in biomarker research applicable to toxicology and medicine

Research on genomic and epigenomic biomarkers is developing rapidly with cutting-edge studies scattered throughout the academic literature, making the status of ongoing scientific activity in this area difficult to ascertain.

Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions delivers a comprehensive and authoritative compilation of up-to-date developments in the application of genomic and epigenomic biomarkers to toxicology, disease prevention, cancer detection, therapeutics, gene therapy, and other areas. With contributions from a collection of internationally recognized investigators, this edited volume offers unique insights into current trends and future directions of research in the discussed areas.

Combining state-of-the-art information on genomic and epigenomic biomarkers from a range of specialists from around the world, this monograph includes:A thorough introduction to microRNAs as non-invasive biomarkers of toxicity and chemical hazardComprehensive explorations of extracellular vesicle-associated miRNAs as toxic biomarkers, as well as transcriptomic applications in toxicology and medicinePractical discussions of circulating miRNAs as biomarkers of metal exposure, as well as microRNAs biomarkers of malignant mesotheliomaIn-depth examinations of the role of noncoding RNAs in innate immune responses perturbed by environmental arsenic with a focus on microRNAs

Perfect for researchers, toxicologists, risk assessors, and regulators,Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions will also earn a place in the libraries of graduate students with an interest in biomarkers, toxicology, agriculture, or the environment.

Saura C. Sahu, PhD, is a former Research Chemist with the Division of Toxicology at the Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition at the United States Food and Drug Administration.

Dedication ix

Preface xi

Acknowledgements xiii

List of Contributors xv

1 Genomic and Epigenomic Biomarkers for Predictive Toxicity and Disease 1
Saura C. Sahu

2 MicroRNAs as Non-invasive Biomarkers of Toxicity and Chemical Hazard: Genomic and Epigenomic Biomarkers of Toxicology and Disease 7
Gail M. Nelson and Brian N. Chorley

3 EV (Extracellular Vesicle)-associated miRNAs as Biomarkers of Toxicity 37
Ryuichi Ono, Yusuke Yoshioka, Yusuke Furukawa, Mie Naruse, Makiko Kuwagata, Takahiro Ochiya, Satoshi Kitajima, and Yoko Hirabayashi

4 Circulating miRNAs as Biomarkers of Toxic Heavy Metal Exposure 63
Alexandra N. Nail, Ana P. Ferragut Cardoso, Mayukh Banerjee, and J. Christopher States

5 MicroRNA Biomarkers of Malignant Mesothelioma 89
Lijin Zhu, Fangfang Zhang, Min Zhang, Hailing Xia, Xiuyuan Yuan, and Yanan Gao

6 Role of Non-coding RNAs in Innate Immune Responses Perturbed by Environmental Arsenic Exposure 101
Liz Saavedra Perez and Benjamin L. King

7 Transcriptomics: Applications in Toxicology and Medicine 133
Pius Joseph Copyrighted Material

8 Network Biology for Biomarker Discovery and Therapy in Cancer 163
Asim Bikas Das

9 Epigenetic Biomarkers: Link to Maternal Exposure and Offspring Health Outcomes 185
Jairus Pulczinski, Moira Mccormick, Yuchen Sun, Musa Watfa, Robert YS Cheng, and Wan-Yee Tang

10 The Role of Dynamic Epigenetic Changes in Modulating Homeostasis after Exposure to Low-dose Environmental Chemicals 213
Chongli Yuan, Jennifer L. Freeman, Junkai Xie, and Han Zhao

11 Emerging Non-invasive Molecular Biomarkers for Early Cancer Detection 229
Jacob Sobota, Yingxue Zhang, Eid Alshammari,and Zhe Yang

12 Aberrant DNA Methylation of Tumor Suppressor Genes and Oncogenes as Cancer Biomarkers 251
Eid Alshammari, Yingxue Zhang, Jacob Sobota, and Zhe Yang

13 SMYD Protein Family as Promising Biomarkers for Cancer Diagnosis and Prognosis 273
Yingxue Zhang, Eid Alshammari, Jacob Sobota, and Zhe Yang

14 Toward Precision Medicine: Epigenetic Alterations in Human Melanoma 309
Carmen Elena Condrat, Elena Codruta Dobrica, Sanda Maria Cretoiu, and Dragos Cretoiu

15 Currents Trends and Future Perspectives in Our Epigenetic Signatures: What a Diet Can Trigger 333
Elena-Codrua Dobric, Mihnea-Alexandru Gman, Matei-Alexandru Cozma, and Sanda Maria Cretoiu

16 Genetic and Epigenetic Biomarkers of Organophosphate Compounds, Dialkyl Phosphate Exposure, and Their Relation to Biological Effects 363
David S. Hernández-Toledano and Libia Vega

17 Genetic, Epigenetic, and Anatomical Factors in Agenesis and Development of Female Reproductive Tract 383
Tadaaki Nakajima, Tomomi Sato, and Taisen Iguchi

18 Cause or Consequence: Epigenomic DNA Methylation Changes in Arsenic- Mediated in Vitro Transformation of Human Prostate Cells 395
B. Alex Merrick, Dhiral P. Phadke, Ruchir R. Shah, Deepak Mav, and Erik J. Tokar

19 Epigenetic Regulation of Sex Determination and Toxicity in Nonmammalian Vertebrates 415
Genki Yamagishi, Taisen Iguchi, and Shinichi Miyagawa

20 Characterization of Genomic and Epigenomic Biomarkers of Nanoparticle Toxicity Using the Zebrafish Model System 449
Athira Sairanthry Suku, Parayanthala Valappil Mohanan, and Jennifer L. Freeman

Index 477