TheHandbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.

Dr. Saura C. Sahu Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration. Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of Hepatotoxicity (Wiley, 2007), Toxicogenomics (Wiley, 2008), Nanotoxicity (Wiley, 2009), and Handbook of Systems Toxicology (Wiley, 2011).

Contributors vii

Preface xi

Acknowledgments xiii

Dedication xv

Abbreviations and Acronyms xvii

Part OneNanotoxicology1

1 Testing Nanotoxicity: An Update of New and Traditional Methods 3
Anna G. Cattaneo, Rosalba Gornati, Giovanni Bernardini, Enrico Sabbioni, Luigi Manzo and Mario Di Gioacchino

2 Considerations forIn VitroNanotoxicity Testing 35
Athena M. Keene, Simona Bancos and Katherine M. Tyner

3In VivoEvaluation of Acute and Chronic Nanotoxicity 65
Hayley Nehoff, Neha N. Parayath, Sebastien Taurin and Khaled Greish

4 Genotoxicity of Silver Nanoparticles 87
Yan Li and Tao Chen

5 Immunotoxicology of Nanomaterials 99
Courtney M. Lappas

6 Neurotoxicity of Nanoparticles 111
Stephen C. Bondy

7 Nanoparticles and Plants: From Toxicity to Activation of Growth 121
Mariya V. Khodakovskaya and Mohamed H. Lahiani

8 Epigallocatechin-3-gallate (EGCG) in or on Nanoparticles: Enhanced Stability and Bioavailability of EGCG Encapsulated in Nanoparticles or Targeted Delivery of Gold Nanoparticles Coated with EGCG 131
Le Zhang, Shanshan Wu, Dongxu Wang, Xiaochun Wan and Jinsong Zhang

Part TwoNanomedicine145

9 Factors Affecting the Oral Bioavailability of Nanomaterials 147
Georgia K. Hinkley and Stephen M. Roberts

10 Nanomedicine in Cancer Treatment 161
Ji-Eun Kim and Myung-Haing Cho

11 Nanomedicine in Diabetes: Using Nanotechnology in Prevention and Management of Diabetes Mellitus 189
Radoslav Savi and Dusica Maysinger

12 Inhalation Pathway as a Promising Portal of Entry: What Has to Be Considered in Designing New Nanomaterials for Biomedical Application? 205
Loretta Müller, Andrea D. Lehmann, Blair D. Johnston, Fabian Blank, Peter Wick, Alke Fink and Barbara Rothen-Rutishauser

13 Nanomedicine for the Brain and the Eye: Disease Management in Poorly Accessible Compartments of the Body 223
Anna G. Cattaneo, Rosalba Gornati, Giovanni Bernardini, Enrico Sabbioni, Luigi Manzo and Mario Di Gioacchino

Part ThreeStem Cell Toxicology249

14 Stem Cells in Toxicity Testing 251
Amy L. Inselman, Cheng Wang, Fang Liu and Deborah K. Hansen

15 Human Stem-Cell-Derived Cardiomyocytes in Drug Discovery and Toxicity Testing 267
Kornélia Szebényi, Adrienn Péntek, Nóra Varga, Zsuzsa Erdei, Gergo  Vöfély, Tamás I. Orbán, Balázs Sarkadi andÁgota Apáti

16 Pluripotent Stem Cells as Tools to Assess Developmental Toxicity: Diversity Instead of Consolidation 299
Nicole R.L. Sparks and Nicole I. zur Nieden

17 Impact of Various Nanosystems on Stem Cell Physiology 309
Anamaria Orza

18 Predictive Mechanisms in Stem Cells: AnIn VitroSystem-Based Method for Testing Carcinogenicity 337
Mireia Vilardell and Ralf Herwig

19 Epigenetic Modifications and Stem Cell Toxicology: Searching for the Missing Link 347
Zacharoula Konsoula and Frank A. Barile

20 Epigenetic Modeling and Stem Cells in Toxicology Testing 359
Sanket R. Gadhia and Frank A. Barile

21 Use of Video Bioinformatics Tools in Stem Cell Toxicology 379
Prue Talbot, Nicole I. zur Nieden, Sabrina Lin, Ivann Martinez, Ben Guan and Bir Bhanu

Author Index I

Subject Index III