Sets the stage for the development of better diagnostic techniques and therapeutics

Featuring contributions from an international team of leading clinicians and biomedical researchers,Molecular Basis of Oxidative Stress reviews the molecular and chemical bases of oxidative stress, describing how oxidative stress can lead to the development of cancer and cardiovascular and neurodegenerative diseases. Moreover, it explains the potential role of free radicals in both the diagnosis and the development of therapeutics to treat disease.

Molecular Basis of Oxidative Stress is logically organized, beginning with a comprehensive discussion of the fundamental chemistry of reactive species. Next, the book:

Presents new mechanistic insights into how oxidative damage of biomolecules occursExamines how these oxidative events effect cellular metabolismInvestigates the role of oxidative stress in the pathogenesis of cancer, neurodegenerative disease, cardiovascular disease, and cystic fibrosisExplores opportunities to improve the diagnosis of disease and the design of new therapeutic agents

Readers will find much novel information, including new radical chemistries and the latest discoveries of how free radicals react with biomolecules. The contributors also present recent findings that help us better understand the initiation of oxidative stress and the mechanisms leading to the pathogenesis of various diseases.

Throughout the book, the use of molecular structures helps readers better understand redox chemistry. In addition, plenty of detailed figures illustrate the mechanisms of oxidative stress and disease pathogenesis.

Examining everything from the basic chemistry of oxidative stress to the pathogenesis of disease,Molecular Basis of Oxidative Stress will help readers continue to explore the nature of oxidative stress and then use that knowledge to develop new approaches to prevent, detect, and treat a broad range of disease conditions.

FREDERICK A. VILLAMENA, PhD, is Associate Professor in the Pharmacology Department of The Ohio State University. Dr. Villamena performs extensive research to develop radical probes and synthetic antioxidants for the treatment of radical-mediated injury such as myocardial infarction. His research draws from many fields, including computational chemistry, organic synthesis, spectroscopy, and molecular biology.

Preface xvii

About the Contributors xix

Contributors xxv

1 Chemistry of Reactive Species 1
Frederick A. Villamena

2 Lipid Peroxidation and Nitration 49
Sean S. Davies and Lilu Guo

3 Protein Posttranslational Modifi cation 71
James L. Hougland, Joseph Darling, and Susan Flynn

4 DNA Oxidation 93
Dessalegn B. Nemera, Amy R. Jones, and Edward J. Merino

5 Downregulation of Antioxidants and Phase 2 Proteins 113
Hong Zhu, Jianmin Wang, Arben Santo, and Yunbo Li

6 Mitochondrial Dysfunction 123
Yeong-Renn Chen

7 NADPH Oxidases: Structure and Function 137
Mark T. Quinn

8 Cell Signaling and Transcription 179
Imran Rehmani, Fange Liu, and Aimin Liu

9 Oxidative Stress and Redox Signaling in Carcinogenesis 203
Rodrigo Franco, Aracely Garcia-Garcia, Thomas B. Kryston,Alexandros G. Georgakilas, Mihalis I. Panayiotidis, and Aglaia Pappa

10 Neurodegeneration from Drugs and Aging-Derived Free Radicals 237
Annmarie Ramkissoon, Aaron M. Shapiro, Margaret M. Loniewska, and Peter G. Wells

11 Cardiac Ischemia and Reperfusion 311
Murugesan Velayutham and Jay L. Zweier

12 Atherosclerosis: Oxidation Hypothesis 329
Chandrakala Aluganti Narasimhulu, Dmitry Litvinov, Xueting Jiang,Zhaohui Yang, and Sampath Parthasarathy

13 Cystic Fibrosis 345
Neal S. Gould and Brian J. Day

14 Biomarkers of Oxidative Stress in Neurodegenerative Diseases 359
Rukhsana Sultana, Giovanna Cenini, and D. Allan Butterfield

15 Synthetic Antioxidants 377
Grégory Durand

References, 398

Index 407