Antibiotics are one of our most important weapons to cover bacterial infections and improve human life. Infectious diseases are the leaders among the challenging drug targets because of the multi-drug resist antimicrobial pathogens and continuous rise in the emerging infections from known and unknown sources. Tyrosine kinases are orally active, small molecules that have a favorable safety profile and can be easily combined with other forms of chemotherapy or radiation therapy. The combination of two pharmacophores into a single molecule is an effective and commonly used direction in modern medicinal chemistry for the exploration of novel and highly active compounds. A variety of safe and effective antiinflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. The pharmacophoric structural features of the selective COX-2 inhibitors possess a central heterocyclic five member ring system bearing two vicinal aryl moieties, such as pyrazole (celecoxib), 2(5H) furanone (rofecoxib), and isoxazole (valdecoxib).

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Dhananjay Mane is working as a Professor and Regional Director, Yashwantrao Chavan Maharashtra Open University, Nashik (MS), India. He has a vast experience of 30 yrs academic and administrative in the university and institute of higher education. He published more than 100 research papers and 10 books. He guided successfully to 10 Ph. D students.