Although various analytical techniques are available for the evaluation of drugs, chromatographic analysis are considered better due to the their stability, reproducibility and sensitivity. In recent years, the development of HPLC methods for the determination of drugs has attracted considerable attention of pharmacokineticians due to their importance in the quality control tests of drugs and their formulations. A world wide competition is in progress for developing rapid, convenient and sensitive HPLC methods in quality control testing. This book provides basic guidelines for the HPLC calibration, and method development for the rapid quantification of cetrizine. This method was validated and applied for the determination of cetrizine in tablets and their stability studies. This book is useful to the pharmacokineticians who are interested in the development and validation of stability indicating HPLC methods for cetrizine HCl and other drugs of same physico-chemical properties.

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Ghulam Murtaza, PhD: Assistant Professor at the COMSATS Institute of Information technology, Abbottabad, Pakistan. M. S. H. Akash, Mphil:Lecturer at GC University Faisalabad,Pakistan. S. N. H. Shah, MPhil:Assistant Professor at Bahauddin Zakariya University,Multan.