This comprehensive handbook on the implementation of short course radiotherapy for the treatment of breast cancer is intended as an up-to-date resource for the clinician. The book opens with a series of chapters on underlying principles and diverse relevant topics, including pathologic anatomy of early-stage breast cancer, radiobiology of accelerated breast irradiation, quality assurance and radiation safety, surgical considerations in partial breast irradiation, and impact of oncoplastic surgery on adjuvant radiotherapy. Individual sections are then devoted to hypofractionated whole breast radiotherapy, accelerated partial breast irradiation, and intraoperative radiotherapy. Each section includes details of patient selection, physics, techniques, data, and toxicity.  The reader is provided with clear guidance on the appropriate use of accelerated forms of adjuvant radiotherapy for treatment of early-stage breast cancer and on various emerging treatment approaches.

Dr. Arthur is currently Professor and Vice Chairman of the  Department of Radiation Oncology , Virginia Commonwealth University. His clinical and research interests include brachytherapy, management of breast and genitourinary malignancies, and soft tissue malignancies. Dr Arthurs primary research interests include clinical studies focusing on the treatment of breast cancer with special interest in the development and use of accelerated treatment for breast cancer.  He is a breast committee member of the NRG Oncology national cooperative trial group.

Dr. Frank Vicini has held multiple academic appointments and authored over 200 peer-reviewed articles. He is involved in numerous clinical studies being the Principal Investigator of several with the goal of improving therapeutic outcomes for all stages of breast cancer, reducing cancer treatment times and minimizing toxicities of healthy tissues and vital organs. He is also listed as one of the fewoncologists in "Best Oncology Doctors in America."

David E. Wazer, MD is chief of radiation oncology for the Lifespan Healthcare System in New England and divides his time between Rhode Island Hospital and Tufts Medical Center in Boston. He is professor and chairman of radiation oncology at both Tufts University School of Medicine and The Alpert Medical School of Brown University. Dr. Wazer has numerous sc

ientific publications, co-edits the premier textbook for radiation oncology,  serves as Editor-in-Chief of the American Journal of Clinical Oncology, and actively conducts clinical and cost/utility research in breast cancer, brachytherapy, melanoma, and several novel radiation therapy technologies.

Dr. Khan has been at the Cancer Institute of New Jersey since 2007 after completing a fellowship in brachytherapy at the Brigham and Womens Hospital at Harvard. Prior to that, he completed a residency in radiation oncology at Rush University Medical Center. Dr. Khans primary focus has been in breast cancer, as well as radiation therapy for central nervous system/brain tumors.  Dr Khan is interested in the discovery of novel radiosensitizers and in advanced modalities of highly conformal radiotherapy, such as image-guided brachytherapy and proton therapy.

PART I: Accelerated Breast Irradiation: History, Rationale, and Controversies.- Pathologic Anatomy of Early-Stage Breast Cancer: Defining the Target.- The Radiobiology of Accelerated Breast Irradiation.- Quality Assurance and Radiation Safety/Medical Events.- Surgical Considerations in Partial Breast Irradiation.- Impact of Oncoplastic Surgery on adjuvant XRT.- Comparison of true cost between modalities in a changing health care system.- PART II: Hypofractionated WBI: Patient Selection.- Physics of HWBI.- Treatment History.- PART III: Accelerated Partial Breast Irradiation: Patient Selection.- Physics of Accelerated Partial Breast Irradiation.- Interstitial brachytherapy.- Intracavitary brachytherapy.- 3D-Conformal external beam radiotherapy.- PART IV: Intra-operative Radiation Therapy: Patient Selection.- Physics of IORT.- 50 kV Photons: Targeted Intraoperative Radiotherapy (TARGIT).- Intraoperative Technique with Electrons.- PART V: Emerging treatment approaches: Extreme hypofractionation (brachytherapy, Gammapod, UK FAST WBI).- APBI for breast augmentations.- Accuboost.- APBI for in-breast recurrence following WBI.- Preoperative partial breast.- Locoregional Hypofractionation.- PART VI: Hypofractionation for metastatic disease: Stereotactic treatment for Oligometastatic disease.- Hypofractionaton for palliation.