This book addresses the molecular biology of noroviruses (NoVs), pathogenesis, viral diversity and its impact on selective pressure, host susceptibility and outbreaks, clinical diagnosis, and the latest advances in the management and treatment of disease caused by NoVs. It offers a detailed analysis of our current understanding of the innate and the adaptive immune responses stimulated by NoVs, and discusses the complexity of the ongoing vaccine development and the urgent need for specific immune correlates of protection to advance the field.

This is the first book on noroviruses. Written by leading specialists, it is essential reading for virologists and immunologists.

Nada Melhem is an Associate Professor at the Faculty of Health Sciences, American University of Beirut, Lebanon. She is currently the Director of the Division of Health Professions and the Chair of the Medical Laboratory Sciences Program. She is also a member of the Center for Infectious Diseases Research, Faculty of Medicine at the American University of Beirut. Melhem serves as a consultant to the National Committee of Communicable Diseases at the Lebanese Ministry of Public Health and a temporary advisor to the World Health Organization (Eastern Mediterranean Regional Office).

Global burden of norovirus.- The virus.- Viral diversity, evolution, and selective pressure.- Pathogenesis and clinical features.- Antinorovirus drugs: current and future perspectives.- Norovirus correlates of protection.- The current status of norovirus vaccine development.