InhaltsangabeChapter 1: Introduction: Metastasis as a Therapeutic Target Richard J. Ablin and Malcolm D. Mason Chapter 2: The Natural History of Prostate Cancer David F. Penson and Peter C. Albertsen Chapter 3: The Search for Genes Which Influence Prostate Cancer Metastasis: A Moving Target? Norman J. Maitland Chapter 4: Polyunsaturated Fatty Acids and Prostate Cancer Metastasis Wen G. Jiang Chapter 5: Role of Prostaglandin Synthesis and Cyclooxygenase-2 in Prostate Cancer and Metastasis Alaa F. Badawi Chapter 6: Cell Cycle Regulation Ruchi M. Newman and Bruce R. Zetter Chapter 7: Epithelial-Mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity Mary J.C. Hendrix, Jun Luo, Elisabeth A. Seftor, Navesh Sharma, Paul M. Heidger Jr., Michael B. Cohen, Robert Bhatty, Jirapat Chungthapong, Richard E.B. Seftor, and David Lubaroff Chapter 8: Orthotopic Metastatic Mouse Models of Prostate Cancer Robert M. Hoffman Chapter 9: ßCatenin, its Binding Partners and Signalling Mechanisms: Implications in Prostate Cancer Gaynor Davies, Gregory M. Harrison, and Malcolm D. Mason Chapter 10: Hepatocyte Growth Factor/Scatter Factor and Prostate Cancer Metastasis Gaynor Davies, Wen G. Jiang, and Malcolm D. Mason Chapter 11: Matrix Degradation in Prostate Cancer Michael J. Wilson and Akhouri A. Sinha Chapter 12: The Biology of Bone Metastases from Prostate Cancer and the Role of Bisphosphonates Noel W. Clarke and Herbert A. Fleisch Chapter 13: Non-Steroidal Anti-Androgen Use as Part of Combined Androgen Blockade Therapy for Metastatic or Locally Advanced Prostate Cancer: a Review of the Evidence on Efficacy and Toxicity Mike Shelley, Charles Bennett, Derek Nathan, and Oliver Sartor Chapter 14: Strategies for the Implementation of Chemotherapy and Radiotherapy Paula Scullin, Joe M. O'Sullivan, and Christopher C. Parker Chapter 15: Immuno-gene Therapy for Metastatic Prostate Cancer Takefumi Satoh, Terry L. Timme, Yehoshua Gdor, Brian J. Miles, Robert J. Amato, Dov Kadmon, and Timothy C. Thompson Chapter 16: Distilling the Past - Envisioning the Future Richard J. Ablin and Malcolm D. Mason