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The Nramp Family - Cover

The Nramp Family

Molecular Biology Intelligence Unit

Erschienen am 25.08.2004
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Bibliografische Daten
ISBN/EAN: 9780306478413
Sprache: Englisch
Umfang: xv, 200 S.
Einband: gebundenes Buch

Beschreibung

InhaltsangabePreface. 1. Mouse Natural Resistance Associated Macrophage Protein 1 (Nramp1): A Key Player in Host Innate Immunity Against Infections; Nada Jabado, Steven Lam-Yuk-Tseung, John R. Forbes and Philippe Gros. Why Mouse Models? Nramp1: A Mouse Host Resistance Locus.- Pathogens Under Nramp1 Control.- Nramp1 Gene and Protein Expression in Macrophages.- The Nramp Gene Family.- Divalent Cation Transport by Nramp Proteins.- Nramp1 Dependent Divalent Cations Transport at the Phagosomal Membrane.- Structure/Function Studies by Site Directed Mutagenesis.- Divalent Cation Transport and Resistance to Infections.- Nramp1 and Phagosomal Maturation. 2. Genetic Susceptibility to Infectious Diseases Linked to NRAMP1 Gene in Farm Animals; Judith Caron, Danielle Malo, Christopher Schutta, Joe W. Templeton and L. Garry Adams. Comparative Genomics.- Nramp1.- Chicken Genomics, Salmonella Infection and NRAMP1.- Bovine Genomics, Brucella abortus Infection and NRAMP1. 3. The NRAMP Genes and Human Susceptibility to Common Diseases; Audrey Poon and Erwin Schurr. NRAMP1 Gene Location and Structure.- NRAMP1 Polymorphisms.- NRAMP1 Function.- NRAMP1 and Infectious Diseases Susceptibility.- NRAMP1 and Autoimmune Diseases Susceptibility.- NRAMP2 Location and Genomic Structure.- NRAMP2 Functions.- NRAMP2 Polymorphisms.- NRAMP2 Polymorphisms and Human Diseases Susceptibility. 4. Pleiotropic Effects of Nramp (Bcg/Lsh/Ity) Gene Expression on Macrophage Functions; Luis F. Barrera and Martin Olivier. Resistance to Three Pathogens Controlled by One Gene.- Bcg/Lsh/Ity Gene Expression in Macrophage.- Bcg/Lsh/Ity Gene Pleiotropic Effects on Macrophage Functions.- Nramp, a Candidate Gene for Bcg/Lsh/Ity Gene.- Impact of Nramp Gene Expression on Macrophage.- Signaling Activity and Functions Regulation. 5. Role of Nramp Family in Pro-Inflammatory Diseases; Jenefer M. Blackwell, Hui-Rong Jiang and Jacqueline K. White. Genetic Associations with Pro-Inflammatory Autoimmune Disease in Man.- Evidence for Gene x Environment Interactions?.- Searching for the Functional Polymorphisms in SLC11A1.- Relating Disease Phenotypes to Pleiotropic Effects of SLC11A1.- A Direct Role for Iron in SLC11A1 Regulated Autoimmune.- Disease Phenotypes?.- Mouse Models to Study Slc11a1 Regulation of Pro-Inflammatory Diseases. 6. Role of Nramp2 (DMT1) in Iron Homeostasis; Nancy C. Andrews. Mammalian Iron Metabolism.- Roles of Nramp2 (DMT1) in Iron Homeostasis.- Nramp2 (DMT1) in Iron Disorders. 7. Molecular Physiology of the H+-coupled Iron Transporter DMT1; Bryan Mackenzie and Matthias A. Hediger. Molecular Mechanisms of DMT1.- Substrate Profile.- Structure-Function Analysis of DMT1.- The Role of DMT1 in the Biology of Iron Transport.- Multiple Splice Forms Reveal Discrete Expression.- Control Mechanisms.- DMT1 and its Association with Human Disease. 8. Cellular and Tissue Expression of Rat DMT1 / Nramp; Evan H. Morgan. Gastrointestinal Tract.- Liver.- Erythroid Tissue.- Brain.- Kidney.- Placenta. 9. Tissue Distribution and Subcellular Localization of Nramp Proteins; François Canonne-Hergaux and Philippe Gros. NRAMP1: Discovery of the Nramp1 Gene.- Tissue and Cellular Expression of Mouse and Human Nramp1 mRNA.- Cellular and Subcellular Expression of the Nramp1 Protein in Macrophages and in Neutrophils.- NRAMP2: Nramp2/DMT1 gene, RNA and Protein Isoforms.- Topology Model of Nramp2/DMT1 Protein.- Nramp2/DMT1: Ubiquitous and Cell Specific Expression.- Nramp2/DMT1 in Epithelial Cells.- Nramp2/DMT1 in Peripheral Tissues.- Nramp2/DMT1 Studies: Rich but Controversial Literature. 10. Plant Metal Transporters with Homology to Proteins of the NRAMP Family; Sebastien Thomine and Julian I. Schroeder. Genomic Analysis of the NRAMP Family in Plant Species.- Functional Characterization of NRAMP Metal Transport.- Properties in Heterologous Expression System

Inhalt

Preface.- Mouse Natural Resistance Associated Macrophage.- Protein 1 (Nramp1): A Key Player in Host Innate Immunity Against Infections.- Genetic Susceptibility to Infectious Diseases Linked to NRAMP1 Gene in Farm Animals.- The NRAMP Genes and Human Susceptibility to Common Diseases.- Pleiotropic Effects of Nramp (Bcg/Lsh/Ity) Gene Expression on Macrophage Functions.- Role of Nramp Family in Pro-Inflammatory Diseases.- Role of Nramp2 (DMT1) in Iron Homeostasis.- Molecular Physiology of the H+-coupled Iron Transporter DMT1.- Cellular and Tissue Expression of Rat DMT1 / Nramp 2.- Tissue Distribution and Subcellular Localization of Nramp Proteins.- Plant Metal Transporters with Homology to Proteins of the NRAMP Family.- The Role of Yeast Nramp Metal Transporters in Manganese and Iron Homeostasis.- Metal-ion Transporters.- From Yeast to Human.- Regulation of Bacterial MntH Genes.- Manganese and Iron Transport by Prokaryotic Nramp Family Transporters.- Role of the Nramp Orthologue, MntH, in the Virulence of Mycobacterium Tuberculosis.- Molecular Evolutionary Analysis of the Nramp Family.- Index.